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Baseline information of the study participants The baseline information of all study participants, including patients and healthy controls, were summarized in Table 1

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In addition, due to the ability of metformin to cross the placenta, continued use of metformin for GDM during pregnancy still raises concerns about its safety and potential adverse effects on the fetus

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In addition, TMAO also activated proteinase C, and induced functional damage of vascular endothelial cells through the PKC/NF-B pathway